We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control.R1c mAb also caused weight loss in leptin-deficient ob/ob mice, leptin receptor-mutant db/db
Aim: Snorkelling is a popular aquatic activity which may result in fatal and non-fatal drowning.However, little is known about the scale of injury, factors impacting risk and strategies for prevention.This review assesses the current literature on snorkelling-related drowning with the aim of assessing available data, improving safety recommendation
Spindle microtubules capture and segregate chromosomes and, therefore, their assembly is an essential event in mitosis.To carry out Proline (L-Proline) their mission, many key players for microtubule formation need to be strictly orchestrated.Particularly, proteins that assemble the spindle need to be translocated at appropriate sites during mitosi
Vascular stretch injury is associated with blunt trauma, vascular surgical procedures, and harvest of human saphenous vein for use in vascular bypass grafting.A Chaste Tree Berry model of subfailure overstretch in rat abdominal aorta was developed to characterize surgical vascular stretch injury.Longitudinal stretch of rat aorta was characterized e
The fluorescence and scattering properties of Prochlorococcus and Synechococcus at Station ALOHA as measured by flow cytometry (termed the FCM phenotype) vary with depth and over a variety of time scales.The variation in FCM phenotypes may reflect GREENS TROPICAL population selection or physiological acclimation to local conditions.Observations bef